Read this essay to examine the nature of tumor suppressor genes and the ways in which their loss can lead to cancer. Also learn about the roles played by all the types of gene mutations, along with non-mutational changes, in converting normal cells into cancer cells. Essay on Tumor Suppressor Genes:
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Biology, 2nd semester exam, cancer. 73 terms. Tumor Suppressor Genes 1. 53 terms. Genes that normally block cell cycle progression are known as tumor suppressors. Tumor suppressors prevent the formation of cancerous tumors when they are working correctly, and tumors may form when they mutate so they no longer work.
Several tumor suppressor genes are now known and some examples are listed in Table 1. In some cancers, tumor formation proceeds through well-defined intermediate stages and the requirement for mutation of a particular gene can be identified with a particular stage in the process. Tumour Supressor Genes and Retinoblastoma.
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More from UK Essays. Biology Essay Writing Service Free Essays More Biology Essays. The mutation of critical genes, including supressor genes, oncogenes and genes involved in DNA repair, leads to genetic instability and to progressive loss of differentiation.
Tumours enlarge because cancer cells lack the ability to balance cell division by cell death (apoptosis) and by forming their own vascular system (angiogenesis).
The overactivity of HDACs, associated with transcriptional repression of tumour supressor genes, can lead to dysregulation of cell differentiation, cell cycle and apoptosis mechanisms, that finally can lead to cancer progression or to higher risk of cancer recurrence.